Drug Intermediate
Drug Iintermediate
Drug intermediates are used as raw materials for the production of bulk drugs, or they can refer to a material produced during synthesis of an API that must undergo further molecular change or processing before it becomes an API. Drug intermediates are hygienically formulated using high grade raw materials and they are used in the pharmaceutical and cosmetic industry[1][2].
Verweise:
- [1]. Ma HC, et al. Homochiral Covalent Organic Framework for Catalytic Asymmetric Synthesis of a Drug Intermediate. J Am Chem Soc. 2020 Jul 22;142(29):12574-12578. [Content Brief]
- [2]. Ramachary D B, et al. Development of pharmaceutical drugs, drug intermediates and ingredients by using direct organo‐click reactions[J]. 2008.
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Drug Intermediate Verwandte Produkte (4655)
Verwandte Produkte (4655)
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L-Lactic acid sodium
0 ImagesSynonyms: (S)-2-Hydroxypropanoic acid sodiumL-lactate Sodium (Sodium (S)-2-hydroxypropanoate) is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid. L-Lactic acid Sodium has antiproliferative activity.
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ALC-0159
0 ImagesALC-0159 presents highly mobile surface PEG chains in a dense brush-like conformation, which can form a hydrophilic barrier, reduce non-specific protein adsorption and macrophage uptake, improve colloidal stability, prolong in vivo circulation time, and affect the cellular uptake of LNPs. ALC-0159 dissociates from the surface of mRNA-LNPs under long-term mechanical oscillation stress, thereby reducing steric hindrance, inducing mRNA-LNP fusion, increasing particle size, and releasing unencapsulated mRNA.
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Fmoc-Arg(Pbf)-OH
0 ImagesFmoc-Arg(Pbf)-OH is an arginine derivative containing amine protecting group Fmoc. Fmoc-Arg(Pbf)-OH is a building block for the introduction of Arg into SPPS (Solid-Phase Peptide Synthesis).
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Acetobromo-α-D-glucuronic acid methyl ester, 98%
0 ImagesSynonyms: Acetobromo-alpha-D-glucuronic acid methyl ester, 98%Acetobromo-α-D-glucuronic acid methyl ester, 98% is a glucuronosyl donor. Acetobromo-α-D-glucuronic acid methyl ester, 98% is applicable to the synthesis of other compounds.
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tert-Butyl 3,9-diazaspiro[5.5]undecane-3-carboxylate
![tert-Butyl 3,9-diazaspiro[5.5]undecane-3-carboxylate](https://file.medchemexpress.com/product_pic/hy-30536.gif "Click to View tert-Butyl 3,9-diazaspiro[5.5]undecane-3-carboxylate Product Detail")
0 Imagestert-Butyl 3,9-diazaspiroundecane-3-carboxylate is a 3,9-diazaspiroundecane-based building block and precursor for synthesizing γ-aminobutyric acid type A (GABAA) receptor antagonists.
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5β-Cholanic acid
0 Images5β-Cholanic acid is a hydrophobic modifier used to modify polymer carriers. 5β-Cholanic acid can improve the acid stability, cell penetration efficiency and drug sustained release ability of nanocarriers, and optimize the oral effectiveness of delivered molecules. 5β-Cholanic acid can covalently bind to Glycol chitosan (GC) to form a GC-CA conjugate, which optimizes the hydrophobic anchoring ability of nanoparticles and enables them to be stably adsorbed on the surface of PLGA nanoparticles. Such nanoparticles can resist dissociation in the gastric acid environment and maintain positive charge to enhance endocytic uptake by intestinal epithelial cells (such as Caco-2 cells). 5β-Cholanic acid can be used in the development of drug delivery systems.
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Naringenin chalcone
0 ImagesNaringenin chalcone is an orally active intermediate in flavonol biosynthesis. Naringenin chalcone induces Apoptosis. Naringenin chalcone inhibits the production of MCP-1 and NO. Naringenin chalcone exhibits anticancer activity against glioblastoma. Naringenin chalcone has anti-inflammatory and anti-allergic properties.
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4-Aminobenzyl alcohol
0 Images4-Aminobenzyl alcohol is a self-eliminating linker. 4-Aminobenzyl alcohol can be used to synthesize the fluorescent probe MB-Van1 targeting Vanin-1.
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HPMC (Viscosity:11250-21000mPa.s)
0 ImagesSynonyms: Hypromellose (Viscosity:11250-21000mPa.s); (Hydroxypropyl)methyl cellulose (Viscosity:11250-21000mPa.s); Celacol HPM 5000 (Viscosity:11250-21000mPa.s)HPMC (Viscosity:11250-21000mPa.s) is a hydrophilic, non-ionic cellulose ether used to form swellable-soluble matrices.
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UDP-glucuronic acid trisodium
0 ImagesSynonyms: Uridine 5'-diphosphoglucuronic acid trisodium saltUDP-glucuronic acid trisodium (Uridine-5'-diphosphoglucuronic acid trisodium salt) is a critical precursor for essential glycoconjugates across biological kingdoms, ranging from mammalian glycosaminoglycans and plant cell wall polysaccharides to bacterial capsule glycoglycerolipids.
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(R)-5,7-Difluorochroman-4-ol
0 Images(R)-5,7-Difluorochroman-4-ol is a drug intermediate for synthesis of various active compounds.
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Sirpiglenastat
0 ImagesSynonyms: DRP-104Sirpiglenastat (DRP-104) is a broad acting glutamine antagonist. Sirpiglenastat has anticancer effects by directly targeting tumor metabolism and simultaneously inducing a potent antitumor immune response.
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DBU
0 ImagesSynonyms: 1,8-Diazabicyclo[5.4.0]undec-7-eneDBU (1,8-diazabicyclo[5.4.0]undec-7-ene) is a bicyclic sterically hindered amidine with strong basicity, which possesses multiple properties such as nucleophilicity and coordination ability. DBU is prone to hydrolysis and can undergo addition, substitution, cyclization and other reactions with various substrates to form derivatives containing its scaffold. DBU can also be used as a catalyst.
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Exatecan Intermediate 2
0 ImagesExatecan Intermediate 2 (Compound B) is an intermediate of Exatecan (DX-8951, HY-13631). Exatecan is an anticancer agent belonging to the class of camptothecin analogs. Exatecan interferes with the proliferation and division of tumor cells by interacting with DNA, thereby inhibiting tumor growth. Exatecan is primarily used for research of a variety of cancers including ovarian, lung and breast cancers.
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tert-Butyl (3-aminobicyclo[1.1.1]pentan-1-yl)carbamate
![tert-Butyl (3-aminobicyclo[1.1.1]pentan-1-yl)carbamate](https://file.medchemexpress.com/product_pic/hy-w054424.gif "Click to View tert-Butyl (3-aminobicyclo[1.1.1]pentan-1-yl)carbamate Product Detail")
0 Imagestert-Butyl (3-aminobicyclo[1.1.1]pentan-1-yl) carbamate is a pharmaceutical intermediate used in the synthesis of various active compounds, such as for the preparation of tetrazole-based eIF2B activators.
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4-Chloro-6,7-dimethoxyquinoline
0 ImagesSynonyms: Oro-6,7-dimethoxyquinol4-Chloro-6,7-dimethoxyquinoline (Oro-6,7-dimethoxyquinol) is a drug intermediate for synthesis of various active compounds.
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tBu2bpy
0 ImagestBu2bpy is a bidentate nitrogen ligand that coordinates with Pt (II) and Pt (IV) to form functional complexes. The tBu2bpy Pt (II) bis-crown ether complex selectively recognizes Mg2+ and Zn2+; both ions significantly enhance the fluorescence of the complex and cause a blue shift of the absorption peak. Its six-coordinate Pt (IV) complex [Pt (X)2Me2 (tBu2bpy)] inhibits the proliferation of tumor cells. tBu2bpy Pt (IV) complexes bind to DNA through multiple interactions including partial intercalation, groove binding, and electrostatic interaction, and can competitively displace ethidium bromide and covalently bind to purine nucleotides. tBu2bpy can be used in relevant research in fields such as organic synthesis.
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6-Chloropyrimidine-4-carboxylic acid
0 Images6-Chloropyrimidine-4-carboxylic acid is a drug intermediate for synthesis of various active compounds.
